Two sample MR report
KCNMA1_Alveolar Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 11 | -0.0871189 | 0.0825735 | 0.3189020 |
| Weighted median | 11 | -0.0374848 | 0.0107382 | 0.0004816 |
| Inverse variance weighted | 11 | -0.0393237 | 0.0082095 | 0.0000017 |
| Simple mode | 11 | -0.0361344 | 0.0166293 | 0.0548967 |
| Weighted mode | 11 | -0.0361344 | 0.0164462 | 0.0526972 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.756475 | 9 | 0.9947597 |
| Inverse variance weighted | 2.094852 | 10 | 0.9955601 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0389416 | 0.0669442 | 0.575046 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000234 | 0 | TRUE | 0.1477323 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
